Our Science

Peer-Reviewed Publications

1) YR Wang, H Zhao, XS Sheng, PE Gambino, B Costello, and K Bojanowski: Protective effect of Fructus Lycii Polysaccharides against time- and hyperthermia-induced damage in cultured seminiferous epithelium J. Ethnopharmacol. 82:169-175, 2002.

2) E Atlas, K Bojanowski, I Mehmi, R Lupu: A deletion mutant of heregulin increases the sensitivity of breast cancer cells to chemotherapy without promoting tumorigenicity. Oncogene. 22:3441-3451, 2003.

3) H Zhao, A Alexeev, E Chang, G Greenburg and K Bojanowski: Lycium barbarum glycoconjugates: effect on whole skin and cultured dermal fibroblasts. Phytomedicine, 12: 132-138, 2005.

4) H Zhao, F Aria, R Mortezaei, YR Wang, XS Sheng and K Bojanowski: SBD.4 Stimulates Regenerative Processes In Vitro and Wound Healing in Genetically Diabetic Mice and in Human Skin/SCID Mouse Chimera. Wound Repair & Regeneration, 14:593-601, 2006.

5) H Zhao, A Alexeev, V Sharma, LD Guzman, K Bojanowski: Effect of SBD.4A - a defined multicomponent preparation of Angelica sinensis - in periodontal regeneration models. Phytother Res. 22:923-928, 2008.

6) J Deneau, T Ahmed, R Blotsky, K Bojanowski: Anti-Diabetic Activity of a Mineraloid Isolate, In Vitro and in Genetically Diabetic Mice. Int. J. Vitam. Nutr. Res. (Switzerland). 81:1- 8, 2011.

7) K Gobis, H Foks, K Bojanowski, E Augustynowicz-Kopeć, A Napiórkowska: Synthesis of novel 3-cyclohexylpropanoic acid-derived nitrogen heterocyclic compounds and their evaluation for tuberculostatic activity. Bioorg Med Chem. 20:37-144, 2012.

8) H Zhao, J Deneau, G O L Che, S Li, F. Vagnini, P Azadi, R Sonon, R Ramjit, S M Y Lee and K Bojanowski: Angelica sinensis Isolate SBD.4: Composition, Gene Expression Profiling, Mechanism of Action, and Effect on Wounds in Rats and Humans. Eur. J. Dermatol. 22:58-67, 2012.

9) K Gobis, H Foks, J Sławiński, A Sikorski, D Trzybiński, E Augustynowicz-Kopeć, A Napiórkowska, K Bojanowski: Synthesis and Biological Activity of Novel Heterocyclic Sulfonyl- carboximidamides Monatshefte für Chemie – Chemical Monthly 144:647-658, 2013.

10) K Bojanowski: Hypodermal delivery of cosmetic actives for improved facial skin morphology and functionality. Int J Cosmet Sci. doi: 10.1111/ics.12077, 2013.

11) RK Chaudhuri, K Bojanowski: Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. Int J Cosmet Sci. 221-230, 2014.

12) H Zhao, K Bojanowski: Hypodermis: the last frontier for facial cosmetics. H&PC Today 9:38-42, 2014.

13) K Gobis, H Foks, K Suchan, E Augustynowicz-Kopeć, A Napiórkowska, K Bojanowski: Novel 2-(2-phenalkyl)-1H-benzo[d]imidazoles as antitubercular agents. Synthesis, biological evaluation and structure-activity relationship. Bioorg Med Chem. pii: S0968-0896(15)00173-X, 2015.

14) H Zhao, K Bojanowski: Dermatologic Uses and Effects of Lycium barbarum. In “Lycium barbarum and human health” Ed. RCC Chang and K Fai, (Springer), 79-8, 2015.

15) K Bojanowski, R Bojanowski: Two methods of oral delivery of resveratrol: a case study. Journal of Aging Research and Clinical Practice (JARCP), 4 (3):185-189, 2015.

16) S Ma, K Gobis, WR Swindell, R Chaudhuri, R Bojanowski, K Bojanowski: Synthesis and activity of the salicylic acid ester of bakuchiol in psoriasis-surrogate keratinocytes and skin substitutes. Clin Exp Dermatol. 42:251-260, 2017.

17) RK Chaudhuri, K Bojanowski: Improvement of Hydration and Epidermal Barrier Function in Human Skin by a Novel Compound Isosorbide Dicaprylate. Int J Cosmet Sci. 39:518-526, 2017.

18) WR Swindell, K Bojanowski, MS Kindy, RMW Chau, D Ko: GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis. Translational Neurodegeneration 7:30, 2018.

19) M Kindy, WR Swindell, K Bojanowski, P Lupinacci, R Bowser, R Nir, M Westlin, J Evans, T Shum, R Chau, D Ko: GM6, an Endogenous Multiple-Target Regulator that Provides a Novel Therapeutic Strategy for Treatment of ALS and Other Neurodegenerative Diseases. Neurotherapeutics 15 (3):820-821, 2018.

20) WR Swindell, K Bojanowski, R Chaudhuri: A Zingerone Analog, Acetyl Zingerone, bolsters matrisome synthesis, inhibits matrix metallopeptidases, and represses IL-17A target gene expression. J Invest Dermatol. 140 (3):602-61, 2020.

21) M Krause, H Foks, D Ziembicka, E Augustynowicz-Kopeć, A Głogowska, I Korona-Głowniak, K Bojanowski, D Siluk, K Gobis K: 4-Substituted picolinohydrazonamides as a new class of potential antitubercular agents. Eur J Med Chem. 15190:112106, 2020.

22) K Bojanowski, P Corona, S Ma, H Zhao: A noninvasive myorelaxant approach resulting in gummy smile improvement-A pilot study. J Cosmet Dermatol. 20 (2):597-601, 2020.

23) K Bojanowski, S Ma, R Applebaum, H Zhao: Transbuccal platform for delivery of lipogenic actives to facial skin: Because fat matters. J Tissue Eng Regen Med. 14(8): 1169-1174, 2020.

24) WR Swindell, K Bojanowski, R Chaudhuri: A novel fumarate, isosorbide di-(methyl fumarate) (IDMF), replicates astrocyte transcriptome responses to dimethyl fumarate (DMF) but specifically down-regulates genes linked to a reactive phenotype. Biochem Biophys Res Commun. 532 (3):475-481., 2020.

25) WR Swindell, K Bojanowski, R Chaudhuri: A standardized Terminalia chebula fruit extract alters the expression of genes associated with skin architecture and barrier formation. Eur. J. Dermatol. 30 (5):469-49, 2020.

26) K Bojanowski, WR Swindell, S Cantor, R Chaudhuri: Isosorbide Di-(Linoleate/Oleate) Stimulates Prodifferentiation Gene Expression to Restore the Epidermal Barrier and Improve Skin Hydration. J Invest Dermatol. 141 (6):1416-1427, 2021.

27) WR Swindell, M Randhawa, G Quijas, K Bojanowski, RK  Chaudhuri: Tetrahexyldecyl Ascorbate (THDC) Degrades Rapidly under Oxidative Stress but Can Be Stabilized by Acetyl Zingerone to Enhance Collagen Production and Antioxidant Effects. Int J Mol Sci. 22 (16):8756, 2021.

28) GP Majewski, S Singh, K Bojanowski: Olive leaf-derived PPAR-α agonist-containing olive leaf-derived complex induces collagen IV in human skin models. Int J Cosmet Sci. 43 (6):662-676, 2021.

29) K Bojanowski, CU Ibeji, P Singh, WR, Swindell RK Chaudhuri. A Sensitization-Free Dimethyl Fumarate Prodrug, Isosorbide Di-(Methyl Fumarate), Provides a Topical Treatment Candidate for Psoriasis. J Invest Dermatol. Innovations. 1 (4):100040. eCollection, 2021.

30) WR Swindell, K Bojanowski, RK Chaudhuri. Transcriptomic Analysis of Fumarate Compounds Identifies Unique Effects of Isosorbide Di-(Methyl Fumarate) on NRF2, NF-kappaB and IRF1 Pathway Genes.  Pharmaceuticals (Basel). 15 (4):461, 2022.

31) G Quijas, ŁP Haliński, K Gobis, R Bojanowski, K Bojanowski. Synthesis and new skin-relevant properties of the salicylic acid ester of bakuchiol.  Nat Prod Res. Jun 21:1-9. doi: 10.1080/14786419.2022.2089882, 2022.

32) GP Majewski, P Marchesi, K Bojanowski. Niacinamide + "Linefade" ameliorate crow's feet wrinkles and facial sagging in a split-face image analysis study.  J Cosmet Dermatol. 2022 Oct 13. doi: 10.1111/jocd.15459.

33) WR Swindell, K Bojanowski, RK Chaudhuri. Isosorbide Fatty Acid Diesters Have Synergistic Anti-Inflammatory Effects in Cytokine-Induced Tissue Culture Models of Atopic Dermatitis. Int J Mol Sci. 2022 Nov 18;23(22):14307.

34) WR Swindell, K Bojanowski, P Singh, M Randhawa, RK Chaudhuri. Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs. JID Innov. 2022 Dec 26;3(3):100178.

35)  D Ziembicka, K Gobis, M Szczesio, A Olczak, E Augustynowicz-Kopeć, A Głogowska, I Korona-Głowniak, K Bojanowski. Synthesis and Structure-Activity Relationship of 2,6-Disubstituted Thiosemicarbazone Derivatives of Pyridine as Potential Antituberculosis Agents. Materials (Basel). 2023 Jan 3;16(1):448

36) JV Gruber, N Terpak, S Massard, A Schwartz, K Bojanowski.Passive Enhancement of Retinol Skin Penetration by Jojoba Oil Measured Using the Skin Parallel Artificial Membrane Permeation Assay (Skin-PAMPA): A Pilot Study. Clin Cosmet Investig Dermatol. 2023 Feb 2;16:317-324. 

37) D Ziembicka, K Gobis, M Szczesio, E Augustynowicz-Kopeć, A Głogowska, I Korona-Głowniak, K Bojanowski.Synthesis and Biological Activity of Piperidinothiosemicarbazones Derived from Aminoazinecarbonitriles. Pharmaceuticals (Basel). 2023 Sep 7;16(9):1267

38)  G Quijas, A Lewińska, M Łukaszewicz, K Bojanowski. New Skin-Relevant Cell Coculture Model With Stratum Corneum-Like Layer. Biomed Res Int.; 2024:1041392. doi: 10.1155/2024/1041392. PMID: 38933176

Other Publications

G Gillis, K Bojanowski, G Majewski, R Bohm: UpRegulex - Sericin peptides from silk protein. Cosmetic Science Technology, 30-33, 2009

R Chaudhuri, K Bojanowski, F. Marchio: Le rétinol et les composés rétinol-like en soins cutanés. Expressions Cosmetiques, 227-233, 2010

BA Green, BL Edison, K Bojanowski, RL Weinkauf: Antiaging bionic and polyhydroxy acids reduce nonenzymatic protein glycation and skin sallowness. Journal of the American Academy of Dermatology 70 (5), AB22-AB22, 2014

WR Swindell, K Bojanowski, M Kindy, T Shum, R Chau, D Ko: GM604 represses tau and down-regulates expression of mitochondrial genes associated with Alzheimer’s disease. F1000Research 5, 2016

WR Swindell, K Bojanowski, M Kindy, T Shum, R Chou, D Ko: GM604 for Parkinson's Disease treatment: pre-clinical findings and results from a pilot placebo-controlled trial F1000Research 6, 2017

Krzysztof Bojanowski, Tai An Pan, Hui Zhao, Rong Guo: Goji (Lycium barbarum) Glycoconjugates: Application in Functional Foods. Chapter 6. Phytochemicals in Goji Berries Applications in Functional Foods, Edited by Xingqian Ye, Yueming Jiang, CRC Press, 06 2020

Presentations & Invited Lectures

K Bojanowski and H Zhao: Importance of glycosylation for the activity of a new anticancer angiogenesis inhibitor SBD.1. Poster at Gordon Conference on Carbohydrates, Tilton, 2001

K Bojanowski: Skin Care through the Protection of Dermal Microcirculation. Invited lecture at Personal Care Ingredients Technology Expo. New York, 2004

K Bojanowski: Product development for niche markets - in vitro validation approach. Invited lecture at Personal Care Ingredients Technology Expo. New York, 2005

H Zhao, F Aria, V Sharma, A Alexeev, R Mortezaei and K Bojanowski: SBD.4 - A Modular Technology for the Development of Products for Skin, Wounds and Periodontal Diseases. UCSF 2006 Life Science Innovation Competition Finals. San Francisco, 2006 (Presentation awarded People's Choice Award)

K Bojanowski: Hybrid Compounds: A Growing Trend in Cosmeceuticals. Strategic Research Institute's (SRI) 4th Annual Cosmeceuticals Conference. New York, 2007

K Bojanowski: Non-clinical Testing of Cosmetic Actives for Special Needs and Aging Skin. ACCELERATING THE FUTURE. Ingredient & Technology Conference New York, 2008.

K Bojanowski, J Deneau, OL Che, SMY Lee, F Vagnini and R Ramjit: SBD.4-Based Wound Dressings: the “Green” Revolution in Chronic Ulcer Management. Symposium on Advanced Wound Care, Anaheim, 2010.

K Gobis, H Foks, E Augustynowicz-Kopeć, and K Bojanowski. Synthesis and tuberculostatic activity of novel 2-(2-cyclohexylethyl)-lH-benzo[ d]imidazoles. Multidisciplinary Conference on Drug Research, Ossa, 2012.

R Chaudhuri, K Bojanowski. Cyclobutane Pyrimidine Dimers, NADPH Oxidase and Peroxynitrite: How Are They All Interlinked? 29th IFSCC Congress, Orlando, 2016.

WR Swindell, K Bojanowski, M Kindy, T Shum, R Chau, D Ko. GM604 for Parkinson's Disease treatment: Pre-clinical findings and results from a pilot placebo-controlled trial. F1000Research 6:28 (doi: 10.7490/f1000research.1113600, 2017.

Ratan K Chaudhuri, Krys Bojanowski, Parvesh Singh. Delayed DNA Damage - How Significant this Pathway is for Skin Damage? NYSCC Annnual Meeting presentation, 2017.

Mark Kindy, William R. Swindell, Krzysztof Bojanowski, Paul Lupinacci, Robert Bowser, Raphael Nir, Tony Shum, Raymond Chau, Dorothy Ko. GM604 –An Endogenous Multiple-Target Regulator that Provides a Novel Therapeutic Strategy for Treatment of ALS and Other Neurodegenerative Diseases. 28th National Symposium on ALS/MND, Boston, 2017.

Krys Bojanowski. Improving Smile Line and Facial Regeneration through Bioadhesive Intraoral Films: The First Dental Office - Friendly Skin Care Cosmetic. 73rd Annual Meeting of the Society of Cosmetic Chemists in New York, Dec. 2019.

 Krys Bojanowski, Geovani Quijas, George Majewski. Improvement of the Dermal-Epidermal Junction (DEJ) and skin appearance by a plant-derived PPAR-α agonist complex. 76rd Annual Meeting of the Society of Cosmetic Chemists in Los Angeles, Dec. 2022.

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